The unique setup of RaPaed-AIDA-TB allows the evaluation of multiple new test candidates and testing approaches:
- Pathogen detection
· Evaluation of the Xpert MTBRIF Ultra® cartridges on different specimen types
· Lipoarabinomannan (LAM) detection in different specimen
Host immune response
· Assessment of the T cell specific immune response:
“T cell activation marker TB"
Host biomarker signatures
· Protein based
· RNA signatures
Furthermore, the project will contribute significantly to the establishment of a biorepository to facilitate future new test evaluation on stored paediatric samples.